atdreon Information Security Stack Exchange • Recommends
On “Using Two-Factor Authentication to Stop Pass-the-Hash”
Matt Weeks, in his Credential Assessment Mapping Privilege Escalation at Scale talk, discusses many techniques to prevent PtH, PtT, and PtK (OPtH).
Starting at 41:50 and up until 48:52, he goes over many prevention angles and gotchas -- link to this video
My favorite recommendations are the rotation of KRBTGT weekly, and, if you can utilize smart cards then rotate the user hashes daily. He also speaks about a generic PtH control with blocking inbound NTLM to the domain.
The DFIR Blog has an excellent three-part series on many other detections and mitigations --
http://dfir-blog.com/2015/11/08/protecting-windows-networks-defeating-pass-the-hash/
http://dfir-blog.com/2015/11/24/protecting-windo…